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Pfizer’s Quest For COVID Vaccine Correlates Of Protection Running Into Roadblocks

 
• By Sarah Karlin-Smith

Pfizer scientists said they are having trouble identifying an immune correlate of protection for the company's COVID-19 vaccine, while other scientists expressed optimism that neutralizing antibodies might eventually be able to be used as a correlate, though there were some questions raised about using them for booster decision making.

Biden gets his booster
President Biden got his Pfizer booster on 27 September. The US government said data on mixing and matching all three US-cleared vaccines for booster purposes is almost ready. • Source: Ken Cedeno/Pool via CNP/MediaPunch

Pfizer Inc. is having difficulty identifying an immune correlate of protection, a measurement of an immune marker that can predict a person’s degree of protection against infection or disease, when inoculated with its COVID-19 vaccine.

A proven correlate would make it easier to license similar vaccines, modify the current vaccine, and expand the populations it is being used, among other goals. At US Food and...

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