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NIH Mix and Match Study Suggests mRNA COVID Vaccines May Offer Stronger Boost Than J&J

 
• By Sarah Karlin-Smith

Though not designed to facilitate inter-group comparisons, a preprint study of heterologous and homologous boosting with the three US available COVID-19 vaccines indicate Johnson and Johnson primary vaccines may get greater protection from an mRNA booster.

NIH National Institue of Allergy and Infectious Diseases building
FDA's vaccine advisors will hear a presentation on mixing and matching COVID-19 booster shots from NIAID on 15 October. • Source: Alamy

People who got a booster dose of an mRNA COVID-19 vaccine following primary vaccination with Johnson & Johnson’s adenovirus COVID-19 vaccine generated a stronger antibody response than J&J patients boosted with another one of the sponsor’s adenovirus shots, new data from the US National Institutes of Health shows, throwing a possible wrench in J&J’s ability to capitalize on US boosters.

The US Food and Drug Administration’s Vaccine and Related Biological Products Advisory Committee is expected to vote on 15 October on an emergency use authorization for homologous boosting with J&J’s vaccine two to

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More from United States

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• By Cathy Kelly

Decision in AstraZeneca’s lawsuit against the Health and Human Services Department is a precedent-setting victory for the government and a blow to manufacturer efforts to block the price negotiation program.

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• By Bridget Silverman

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• By Derrick Gingery, Sue Sutter, and Nielsen Hobbs

Pink Sheet editors discuss the appointment of Vinay Prasad as the new director of the Center for Biologics Evaluation and Research and revelations that FDA layoffs now are hindering development of guidance documents.

US FDA Restoring Some Library Resources

 
• By Sue Sutter and Derrick Gingery

Agency staff once again have access to the Lexis-Nexis legal and news database, but are still waiting for access to journals, and laid off librarians have not been reinstated.

More from North America

Recent and Upcoming FDA Advisory Committee Meetings

 
• By Sue Sutter

Recent and upcoming US FDA advisory committee meetings and a summary of the topics covered.

Most Favored Nation Pricing Policy Floated In Medicaid, Coming Back To Medicare?

 
• By Cathy Kelly

President Trump's ongoing interest in the policy, which would ensure the US government pays no more for prescription drugs than the lowest price available in comparable countries, continues to gain attention.

US FDA Advisory Committee Misperceptions Abound … At HHS

 
• By Michael McCaughan

HHS Secretary Robert F. Kennedy Jr. regularly decries the “conflicts of interest” he believes abound in advisory committees, but his concerns, as well as a recent “policy directive” eliminating industry representatives, seem driven by a misunderstanding of the panels’ jobs.