FDA One Step Closer To Makena Withdrawal After Hearing Officer Echoes Advisory Panel’s Advice

In a memo to Commissioner Califf and Chief Scientist Bumpus, Celia Witten focuses the final Makena decisionmakers on the key factors she believes should be used to determine the drug’s market status.

dominoes falling
Revocation of Makena’s Accelerated Approval Looks Increasingly Likely • Source: Shutterstock

The US Food and Drug Administration's withdrawal of Covis Pharma's preterm birth prevention drug Makena seems increasingly inevitable following the 20 January endorsement of pulling the accelerated approval by Celia Witten, deputy director of the Center for Biologics Evaluation and Research.

Witten’s recommendation adds to the strong 14-1 FDA advisory committee vote in October against keeping Makena on the market while another confirmatory study is conducted. Witten served as the presiding officer over that three-day meeting

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