EU Revokes Intercept/Advanz’s Ocaliva Approval As Moment Of Reckoning Nears in US

The EU marketing authorization for the primary biliary cholangitis treatment has now been revoked. Meanwhile the drug's approval is in jeopardy in the US, where an advisory committee will opine on whether the accelerated approval drug has confirmed clinical benefit.

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Ocaliva's continued marketing in the EU and US is at risk. • Source: Shutterstock

September is shaping up to be a make-or-break month for Intercept Pharmaceuticals, Inc. and Advanz Pharma Corp.’s approved liver disease drug Ocaliva (obeticholic acid) in the EU and US.

Key Takeaways
  • The European Commission has revoked Advanz's conditional marketing authorization for Ocaliva, for treating PBC, after EU regulators decided that the drug's clinical benefits had not been confirmed.

  • In the US, Intercept will defend the drug before the Gastrointestinal Drugs Advisory Committee, which could be asked whether the PBC indication should be withdrawn if clinical benefit has not been demonstrated

The European Commission has revoked the drug’s conditional marketing authorization for treating primary biliary cholangitis (PBC) following a recommendation to do so from the European Medicines Agency’s human

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