Gene Therapies: Bluebird Bio Presses US FDA To Reverse Denial Of Lyfgenia Priority Review Voucher

Lyfgenia and Zynteglo comprise complex mixtures of transduced cells that represent different active ingredients, the company said in administrative appeals to the FDA. Two lawmakers also raised bipartisan concerns about the agency’s decision on the voucher request for the sickle cell disease treatment.

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Bluebird bio wants the FDA to reverse its decision denying the company a priority review voucher. (Shutterstock)

Bluebird bio’s pursuit of a priority review voucher for its approved sickle cell treatment Lyfgenia is calling attention to the US Food and Drug Administration’s definition of “active ingredient” for gene therapies.

The company has appealed the FDA’s denial of a rare pediatric disease PRV, asserting the agency’s justification is scientifically incorrect and misaligned with congressional intent.

Key Takeaways
  • Bluebird bio wants the FDA’s denial of a rare pediatric disease priority review voucher for the gene therapy Lyfgenia reversed.
  • In a...

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