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Lilly In Collaboration To Screen NIH Pharmaceuticals Collection, Make Pharmacology Data Public

 
• By Shirley Haley

Repurposing opportunities are unlikely in this NCATS/Lilly project, which has the loftier goal of furthering understanding of how small molecule drugs actually work in complex human systems in order to improve drug development for the entire “research universe.”

Lilly Research Laboratories will apply its Phenotypic Drug Discovery assays to 3,800 approved and investigational small molecule drugs from the National Institutes of Health’s collection of all known drugs approved for human use, with the goal of improving drug development by providing a better understanding of how drugs work in complex human systems. The project should take 12 to 18 months, and all data will be made public following the Human Genome Project model.

“If we’re going to get better at making drugs that do good things and don’t do bad things, then we have to understand on a systems level what these drugs do writ large … not on one target but on all targets,” said Christopher Austin, director of the NIH National Center for Advancing Translational Sciences’ Division of Preclinical Innovation

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