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Lilly Shows Off R&D Progress With A Pain Franchise Built On New Mechanisms

With galcanezumab for cluster headaches and migraine and tanezumab for osteoarthritis, lower back pain and cancer pain, Lilly soon could have an up-and-running pain franchise bolstering its long-term, internal R&D strategy.

Though pain hasn't traditionally been an area of focus for Eli Lilly & Co., the firm's burgeoning franchise includes two potential first-in-class candidates nearing regulatory filings. Coming out of a May 25 R&D review, analysts are thinking the pharma's new area of specialization may be significantly undervalued by investors.

Lilly's R&D effort in pain is led by a pair of Phase III assets in new mechanisms – galcanezumab, a calcitonin gene-related peptide (CGRP) receptor antagonist in development for cluster headaches and both chronic and episodic migraine, and tanezumab, a nerve growth factor (NGF) antibody partnered with Pfizer Inc

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