FDA Panel Will Have To Resolve Bleeding Risk With Merck’s Vorapaxar

Novel antiplatelet product has suffered from excess bleeding rates in clinical trials and is searching for an appropriate patient population, after initial hopes of being a blockbuster.

Advisory committee members will have to grapple with bleeding risks associated with Merck & Co. Inc.’s platelet inhibitor vorapaxar, a product once thought to be a potential blockbuster, but now likely searching for an ideal population for use.

Vorapaxar, proposed trade name Zontivity, will go before the Cardiovascular and Renal Drugs Advisory Committee Jan. 15 as part of a three-day meeting; Chelsea Therapeutics International Ltd

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