Lessons From ALLHAT and CATIE

Before the US invests billions in a national center on comparative effectiveness, it may be worth considering whether current efforts have any real impact on prescribing practices. Do large-scale clinical trials add anything to the practice of health care?

Is the debate on a national center on comparative effectiveness research a classic case of putting the cart before the horse?

Policymakers acknowledge that there are significant questions that still need to be answered about an expanded effort on comparative effectiveness...

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