Biosimilar Advisory Committee Reviews: Necessity Or Nuisance?

FDA panelists' confusion over biosimilarity and overwhelming approval endorsements following glowing agency reviews suggest the meetings may not be having much impact on FDA deliberations; however, agency sees an opportunity to learn from what its external experts don't understand about biosimilars.

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FDA typically brings new product applications to advisory committees to get its external experts' views on the robustness of the clinical efficacy and safety data and ability of the products to fit into clinical practice.

In the case of the early biosimilar advisory committee meetings, however, a different dynamic has been evident, with FDA having to explain the relevance the analytical characterization and clinical data and respond to

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