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Efficacy Studies Not Enough? Consider GSK's Salford Lung Study As New Model

Full results from asthma patients included in the Salford Lung Study provide powerful support for the use of “real world” effectiveness studies as a more relevant form of evidence to inform prescribing choices and improve patient outcomes, particularly in what turned out to be a general population of asthmatics that were still suffering symptoms under usual care.

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Clean air is important to asthmatics; real world evidence may change clinical practice • Source: Shutterstock.

The full results of the asthma part of the GlaxoSmithKline PLC’s Salford Lung Study have confirmed the beneficial effects of the once-daily inhaler combination Relvar Ellipta (fluticasone furoate/vilanterol, known as Breo Ellipta in the US) on asthma symptoms compared with usual care, in a “real-world” clinical effectiveness study that calls into question the dominance of double-blind randomized efficacy studies in supporting clinical guidelines and prescribing decisions that drive medicines’ market share and, ultimately, company profits.

The lead investigator for the Salford Lung Study, Ashley Woodcock, professor of respiratory medicine at the University of Manchester, has...

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