US FDA Review Of Akebia’s Vafseo Informed By Roxadustat, Daprodustat Safety Concerns

Vadadustat's review overlapped with two other oral HIF-PH class drugs. Safety issues with FibroGen/AstraZeneca’s roxadustat drew attention during vadadustat's first-cycle review, while GSK’s Jesduvroq labeling and postmarketing requirements informed the second-cycle approval.

Drug Review Profile: Vafseo
The FDA's review of Vafseo included a close look at the safety issues flagged for two other drugs. • Source: Shutterstock

The US Food and Drug Administration leveraged safety information from two other same-in-class drugs in its review of Akebia Therapeutics, Inc.’s Vafseo (vadadustat) for chronic kidney disease patients with anemia.

More from Drug Review Profiles

More from Product Reviews