Three Strikes But Not Out: GSK Maneuvers Through A Third R&D Setback

GlaxoSmithKline’s decision to end a Phase III trial testing the cancer immunotherapy MAGE-A3 in NSCLC is no surprise, following disappointing results in two trials, but coupled with other disappointing R&D news it puts more pressure on the company to deliver on its respiratory launches.

GlaxoSmithKline PLC’s announcement April 2 that it has stopped a Phase III trial of its MAGE-A3 cancer vaccine in non-small cell lung cancer patients wasn’t a surprise, but as the third piece of disappointing R&D news for the company in one week, it does put more pressure on GSK to deliver on its recent drug launches.

GSK already reported disappointing data on MAGE-A3, most recently in March when the Phase III NSCLC trial failed to demonstrate an efficacy benefit in patients over placebo, but also in...

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