Cancer Trials & Tribulations: Combinations Are Easier Said Than Done

Combinations of checkpoint inhibitors and targeted drugs are said to hold the key to better, more durable results in the future. But recent studies highlighted some big challenges, like unexpected toxicities, prompting a call for more preclinical research to better predict winning combinations.

There’s a lot of excitement about “rational combinations” being the key to turning cancer into a manageable chronic condition, but the early clinical experience indicates that it may not be as easy as hoped to unlock that potential.

While industry and investigators alike are eager to make leaps and bounds toward combination approaches that could break the lock...

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