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Beta/Islet Cell Regeneration Leads Diabetes Deal-Making This Decade

A review of deal-making in the diabetes space since 2010 finds deals around technology to regenerate pancreatic beta cells and/or islet cells as the hottest mechanism of action. Thirteen deals in this area out-number the combined deals involving the DPP-4, SGLT-2 and GLP-1 mechanisms during that period.

With projections that the global diabetes population will grow from 366 million currently to approximately 552 million by 2030, driven by adult-onset type 2 diabetes, biopharma deal-making in diabetes has run hot and heavy this decade. While a handful of deals centered on familiar classes of drugs such as insulin and insulin analogs, as well as DPP-4 and SGLT-2 inhibitors and GLP-1 agonists, there has been a noticeable wave of transactions around another technology – mechanisms to generate insulin-producing B cells in the pancreas.

Such technologies, including those focused on generation of pancreatic islet cells, which are formed by B cells, have been at...

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