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Epizyme Execs On Company’s IPO, Clinical Progress And Diagnostic Strategy

 
• By Michael Goodman

Epizyme and its partners have moved two programs into the clinic and will start an expansion trial for the DOT1L program later this year. It has also struck deals for companion diagnostics, making steady progress personalized medicine solutions for patients with genetically defined cancers within five years of starting clinical trials. CEO Robert Gould and Exec VP Jason Rhodes take stock of the company’s progress.

Hot off a successful IPO in late May, Epizyme Inc. reported steady progress in its collaborations with Celgene Corp. and Eisai Co. Ltd. Both partners have moved their programs into Phase I dose escalation trials and are planning expansion trials to begin over the next year. Epizyme retains U.S. rights to the DOT1L program partnered with Celgene, and a U.S. co-promotion option in the EZH2 program partnered with Eisai [See Deal] and [See Deal]. Earlier in 2013, the partners also announced deals to develop companion diagnostics for these compounds with Abbott Laboratories Inc. and Roche[See Deal].

Epizyme is on track to make good on its plan to become an independent, U.S.-focused, commercial oncology company within five...

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