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Head-To-Head Lung Data Support Boehringer’s Gilotrif Over Iressa

 
• By Emily Hayes

Final results from the LUX-Lung 7 trial suggest superior efficacy for Boehringer’s EGFR inhibitor Gilotrif vs. AstraZeneca’s Iressa, albeit with a small absolute improvement in progression-free survival and a higher rate of severe diarrhea.

Final data from a head-to-head trial against AstraZeneca PLC’s EGFR inhibitor in first-line EGFR-positive non-small cell lung cancer give Boehringer Ingelheim GMBH’s first cancer drug Gilotrif (afatinib) a bit of a boost in terms of efficacy, while elucidating differences in severe side effect profiles between the agents.

In the first-line LUX-Lung 7 trial of 319 NSCLC patients, Gilotrif demonstrated a statistically significant 27% improvement in median progression-free survival compared to Iressa

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