Avastin Takes One Step Forward, One Step Back At ASCO

Genentech’s bevacizumab was the subject of one study supporting use in cervical cancer and one failing to show an effect in first-line brain cancer. A separate study repeated the disappointing brain cancer results, but the sponsor sees a silver lining in the quality of life dataset.

CHICAGO – With the failure of Avastin to improve overall survival in a pair of studies in first-line glioblastoma, Roche/Genentech Inc. is again in the position of taking discordant confirmatory data to FDA in support of an accelerated approval, only this time they may have support from quality-of-life data.

Two separate studies looking at Avastin (bevacizumab) in first-line glioblastoma multiforme were presented at the American Society of Clinical Oncology...

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