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Yervoy/Nivolumab May Need Stronger Survival Data To Be First Choice In Melanoma

 
• By Emily Hayes

Bristol’s combo demonstrates similar response rate as PD-1 alone, but with much better survival rates in a small melanoma study presented at ASCO. Due to toxicities, including one death, some say combination would need to shore up survival benefit to become first choice in frontline therapy.

CHICAGO – The combination of Bristol-Myers Squibb Co.’s CTLA-4 inhibitor Yervoy (ipilimumab) and PD-1 inhibitor nivolumab will need to show very high survival rates in large studies to secure a role in frontline treatment of melanoma, in light of the significant toxicities for the combo and the strong performance of PD-1 monotherapy, said specialists at the American Society of Clinical Oncology annual meeting.

In follow-up data for the combo in 53 Stage 3/4 melanoma patients taking part in a broader Phase I trial,...

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