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With VERTIS SITA2 On Board, Merck Eyes Broad Initial Approval For Ertugliflozin

 
• By Aine Slowey and Emily Hayes

In an interview at the European Association for the Study of Diabetes meeting, Merck exec Sam Engel explains the rationale behind the clinical trial strategy for the SGLT-2 inhibitor ertugliflozin, as it gears up with partner Pfizer for filings by the end of this year.

Results from the VERTIS SITA2 combination study for Merck & Co. Inc./Pfizer Inc.'s SGLT-2 inhibitor ertugliflozin will add to the range of trials that will support regulatory filings – a range the companies have kept broad with the aim of covering the broad spectrum of type 2 diabetes with the initial submission.

The partners aim to file the drug as a monotherapy as well as part of two fixed-dose combinations – with...

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