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Cancer Accelerated Approval On Trial: Advisors With Conflict-Of-Interest Waivers More Likely To Support Industry

 
• By Sarah Karlin-Smith

US FDA Oncologic Drugs Advisory Committee panelists who were granted financial conflict-of-interest waivers to participate in the agency’s multi-day review of accelerated approvals for three immunotherapies voted in favor of keeping the indications at issue on market more than three-quarters of the time. Non-conflicted experts voted in favor only two-thirds of the time. One of the six panel outcomes would have been different without the conflicted members’ votes.

Scales with money and votes
ODAC panelists with conflict-of-interest waivers supported industry most of the time. • Source: Andrii Yalanskyi /Alamy Stock Photo

Members of the US Food and Drug Administration Oncologics Drug Advisory Committee who received conflict-of-interest waivers to participate in the agency’s recent three-day meeting to review the accelerated approval of six checkpoint inhibitor indications were more likely to vote in favor of keeping the indications on market compared to panelists without such conflicts.

Panelists with waivers voted in favor of the drugs despite failure to confirm clinical benefit in post-market trials 76

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