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Zolgensma Provides No Proven Benefit Over Spinraza In SMA, Says German HTA

IQWiG Laments Lack Of Comparative Data

 
• By Francesca Bruce

IQWiG, Germany’s health technology appraisal institute, has found that Novartis’s gene therapy Zolgensma offers no additional benefit compared with Biogen’s Spinraza for treating spinal muscular atrophy, while Roche’s Evrysdi offers a hint of benefit in one patient group.

SMA
German HTA Compares SMA Treatments • Source: Alamy

Novartis AG says it wants a rethink of the way medicines are valued, and Roche Holding AG would like the German system for evaluating medicines to be more open to real world evidence.

The comments come after the German health technology appraisal institute, IQWiG, carried out separate benefit assessments comparing Roche’s Evrysdi (risdiplam) and Novartis’s gene therapy Zolgensma (onasemnogene abeparvovec) with Biogen’s Spinraza

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