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In Vitro Triumph: European Pharmacopoeia Abolishes Rabbit Pyrogen Test

 
• By Neena Brizmohun

The use of the RPT is to no longer be required in any text of the European Pharmacopoeia and medicine developers will have to select a suitable in vitro test to control the pyrogenicity of their product.

The European Pharmacopoeia is waving goodbye to the rabbit pyrogen test • Source: Shutterstock

The European Pharmacopoeia is abolishing the use of the traditional rabbit pyrogen test (RPT), in a move described as a major achievement for animal welfare and the advancement of modern in vitro approaches, and which will send out a strong message globally.

As of 1 July 2025, the use of the RPT will no longer be required in any text of the European Pharmacopoeia and it will be the responsibility of medicine developers to select a suitable in vitro test (eg, the

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